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Compound Detail

CHEMBL4170050

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CCC1=CC2CN3CCc4c([nH]c5ccccc45)[C@@](C(=O)OC)(C2)C13

Basic Information

ChEMBL ID CHEMBL4170050
Phase Preclinical
Structure Type MOL
InChI Key CMKFQVZJOWHHDV-BPLLPPDFSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

336.4
MW (Da)
3.18
ALogP
3
HBA
1
HBD
45.3
PSA (Ų)
0.68
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C21H24N2O2
MW 336.44
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness 1.47

Activity Summary

IC50 1 meas. best 4.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Chlamydia pneumoniae
CHEMBL612694
IC50 4.28 4.28 52600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Chlamydia pneumoniae IC50 = 52600.0 nM 4.28 Antichlamydial activity against Chlamydia pneumoniae K7 infected in HL cells aft... 29043803

Literature References

PubMed DOI Target Context # Activities
29043803 10.1021/acs.jnatprod.6b01052 Chlamydia pneumoniae 2
29043803 10.1021/acs.jnatprod.6b01052 HL 1

Data from ChEMBL 36 via Core Engine