Compound Detail
CHEMBL4174669
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Basic Information
| ChEMBL ID | CHEMBL4174669 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MQUZTKXBCFOZRW-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
453.5
MW (Da)
5.33
ALogP
8
HBA
2
HBD
106.7
PSA (Ų)
0.37
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.04
Ki 1 meas. best 9.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 4 CHEMBL1163125 | Ki | 9.15 | 9.15 | 0.7 | 1 |
| Bromodomain-containing protein 4 CHEMBL1163125 | IC50 | 8.04 | 8.04 | 9.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 4 | Ki | = | 0.7 | nM | 9.15 | Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1... | 30015487 |
| Bromodomain-containing protein 4 | IC50 | = | 9.1 | nM | 8.04 | Inhibition of FAM-labeled ZBA248 binding to recombinant human BRD4 bromodomain 1... | 30015487 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30015487 | 10.1021/acs.jmedchem.8b00483 | Bromodomain-containing protein 4 | 2 |
Data from ChEMBL 36 via Core Engine