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Compound Detail

CHEMBL4176476

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CN(C)CCNC(=O)Nc1nc2[nH]cnc2c(=O)[nH]1

Basic Information

ChEMBL ID CHEMBL4176476
Phase Preclinical
Structure Type MOL
InChI Key ANGNDCDXMDKSRN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

265.3
MW (Da)
-0.67
ALogP
5
HBA
4
HBD
118.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H15N7O2
MW 265.28
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness -1.35

Activity Summary

Kd 1 meas. best 5.69

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 5.69 5.69 2060.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 2060.0 nM 5.69 Binding affinity to Clostridium difficile [5'-32P]guaA riboswitch by polyacrylam... 29220796

Literature References

PubMed DOI Target Context # Activities
29220796 10.1016/j.ejmech.2017.11.079 Clostridioides difficile 1
29220796 10.1016/j.ejmech.2017.11.079 Escherichia coli 1
29220796 10.1016/j.ejmech.2017.11.079 Unchecked 1

Data from ChEMBL 36 via Core Engine