Assay Detail
Binding
CHEMBL4143516
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Binding affinity to Clostridium difficile [5'-32P]guaA riboswitch by polyacrylamide gel electrophoresis method
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridioides difficile |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 42 | 5.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219568 | GUANINE | 3.0 | 1 | 8.70 |
| CHEMBL4164786 | — | — | 1 | 6.50 |
| CHEMBL4161199 | — | — | 1 | 6.35 |
| CHEMBL4171810 | — | — | 1 | 6.25 |
| CHEMBL4161375 | — | — | 1 | 6.20 |
| CHEMBL133214 | — | — | 1 | 6.03 |
| CHEMBL1224659 | — | — | 1 | 5.98 |
| CHEMBL4168054 | — | — | 1 | 5.74 |
| CHEMBL4176476 | — | — | 1 | 5.69 |
| CHEMBL4176187 | — | — | 1 | 5.66 |
| CHEMBL4168998 | — | — | 1 | 5.62 |
| CHEMBL4169532 | — | — | 1 | 5.57 |
| CHEMBL305113 | — | — | 1 | 5.40 |
| CHEMBL4161073 | — | — | 1 | 5.19 |
| CHEMBL4159196 | — | — | 1 | 5.13 |
| CHEMBL1230674 | 9-Methylguanine | — | 1 | 5.09 |
| CHEMBL4165572 | — | — | 1 | 5.01 |
| CHEMBL4176070 | — | — | 1 | 4.91 |
| CHEMBL4160133 | — | — | 1 | 4.79 |
| CHEMBL4163504 | — | — | 1 | 4.68 |
| CHEMBL4163624 | — | — | 1 | 4.61 |
| CHEMBL4170763 | — | — | 1 | 4.60 |
| CHEMBL1867153 | — | — | 1 | 4.60 |
| CHEMBL4165864 | — | — | 1 | 4.56 |
| CHEMBL4161615 | — | — | 1 | 4.53 |
| CHEMBL4172681 | — | — | 1 | 4.32 |
| CHEMBL4168221 | — | — | 1 | 4.17 |
| CHEMBL4162822 | — | — | 1 | 4.16 |
| CHEMBL1864419 | — | — | 1 | 4.15 |
| CHEMBL4169051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219568 | GUANINE | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4164786 | — | Kd | = | 320.0 | nM | 6.50 |
| CHEMBL4161199 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL4171810 | — | Kd | = | 560.0 | nM | 6.25 |
| CHEMBL4161375 | — | Kd | = | 630.0 | nM | 6.20 |
| CHEMBL133214 | — | Kd | = | 930.0 | nM | 6.03 |
| CHEMBL1224659 | — | Kd | = | 1050.0 | nM | 5.98 |
| CHEMBL4168054 | — | Kd | = | 1810.0 | nM | 5.74 |
| CHEMBL4176476 | — | Kd | = | 2060.0 | nM | 5.69 |
| CHEMBL4176187 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL4168998 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL4169532 | — | Kd | = | 2670.0 | nM | 5.57 |
| CHEMBL305113 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL4161073 | — | Kd | = | 6500.0 | nM | 5.19 |
| CHEMBL4159196 | — | Kd | = | 7400.0 | nM | 5.13 |
| CHEMBL1230674 | 9-Methylguanine | Kd | = | 8100.0 | nM | 5.09 |
| CHEMBL4165572 | — | Kd | = | 9800.0 | nM | 5.01 |
| CHEMBL4176070 | — | Kd | = | 12300.0 | nM | 4.91 |
| CHEMBL4160133 | — | Kd | = | 16400.0 | nM | 4.79 |
| CHEMBL4163504 | — | Kd | = | 21000.0 | nM | 4.68 |
| CHEMBL4163624 | — | Kd | = | 24400.0 | nM | 4.61 |
| CHEMBL4170763 | — | Kd | = | 25000.0 | nM | 4.60 |
| CHEMBL1867153 | — | Kd | = | 25200.0 | nM | 4.60 |
| CHEMBL4165864 | — | Kd | = | 27600.0 | nM | 4.56 |
| CHEMBL4161615 | — | Kd | = | 29400.0 | nM | 4.53 |
| CHEMBL4172681 | — | Kd | = | 48300.0 | nM | 4.32 |
| CHEMBL4168221 | — | Kd | = | 68300.0 | nM | 4.17 |
| CHEMBL4162822 | — | Kd | = | 68900.0 | nM | 4.16 |
| CHEMBL1864419 | — | Kd | = | 71300.0 | nM | 4.15 |
| CHEMBL4175253 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4174303 | — | Kd | = | 300300.0 | nM | - |
| CHEMBL4175830 | — | Kd | = | 139900.0 | nM | - |
| CHEMBL4162135 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL33416 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4175789 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4167932 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4169294 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4173274 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4162581 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4165218 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4171397 | — | Kd | > | 1000000.0 | nM | - |
| CHEMBL4169051 | — | Kd | > | 1000000.0 | nM | - |