Compound Detail
CHEMBL419685
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL419685 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LRYLPWSPRBLZLM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
409.6
MW (Da)
4.24
ALogP
3
HBA
2
HBD
44.4
PSA (Ų)
0.55
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.1 | 6.1 | 790.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 790.0 | nM | 6.1 | Antagonistic activity against Ca++permeable Ionotropic glutamate receptor AMPA a... | 11551773 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Glutamate receptor ionotropic, AMPA | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Rattus norvegicus | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine