Assay Detail
Functional
CHEMBL702015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against Ca++permeable Ionotropic glutamate receptor AMPA as concentration of compound that reduces the inward current induced by kainate by 50% in Xenopus oocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of diaminobutane derivatives as potent Ca(2+)-permeable AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.32 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22366 | — | — | 1 | 6.72 |
| CHEMBL90950 | — | — | 1 | 6.60 |
| CHEMBL315554 | — | — | 1 | 6.41 |
| CHEMBL90895 | — | — | 1 | 6.28 |
| CHEMBL25101 | — | — | 1 | 6.16 |
| CHEMBL91247 | — | — | 1 | 6.14 |
| CHEMBL316188 | — | — | 1 | 6.13 |
| CHEMBL419685 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22366 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL90950 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL315554 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL90895 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL25101 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL91247 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL316188 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL419685 | — | IC50 | = | 790.0 | nM | 6.10 |