Compound Detail
CHEMBL90950
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Basic Information
| ChEMBL ID | CHEMBL90950 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NTDMYRNASRNVJL-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
449.7
MW (Da)
5.16
ALogP
3
HBA
2
HBD
44.4
PSA (Ų)
0.47
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.6 | 6.6 | 250.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 250.0 | nM | 6.6 | Antagonistic activity against Ca++permeable Ionotropic glutamate receptor AMPA a... | 11551773 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Glutamate receptor ionotropic, AMPA | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Rattus norvegicus | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | No relevant target | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Glutamate receptor 3 | 1 |
| 11551773 | 10.1016/s0960-894x(01)00530-3 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine