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Compound Detail

CHEMBL420173

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CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)c1ccc(C(=O)OC)cc1-2

Basic Information

ChEMBL ID CHEMBL420173
Phase Preclinical
Structure Type MOL
InChI Key WLHJLEXNCPIFTG-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

410.6
MW (Da)
6.72
ALogP
4
HBA
1
HBD
55.8
PSA (Ų)
0.41
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H34O4
MW 410.55
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness 0.85

Activity Summary

Ki 2 meas. best 8.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
Ki 8.42 8.42 3.8 1
Cannabinoid receptor 1
CHEMBL218
Ki 7.85 7.85 14.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11020293 10.1021/jm0001572 Cannabinoid receptor 1 1
11020293 10.1021/jm0001572 Cannabinoid receptor 2 1
11020293 10.1021/jm0001572 Cannabinoid receptor 1

Data from ChEMBL 36 via Core Engine