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Compound Detail

CHEMBL4202508

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Cc1n[nH]c2c(NCCC(C)C)ncnc12

Basic Information

ChEMBL ID CHEMBL4202508
Phase Preclinical
Structure Type MOL
InChI Key WYSHMZZQNOKGRO-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

219.3
MW (Da)
2.12
ALogP
4
HBA
2
HBD
66.5
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H17N5
MW 219.29
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -1.32

Activity Summary

IC50 2 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nicotiana tabacum
CHEMBL613059
IC50 7.0 6.57 100.0 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Nicotiana tabacum IC50 = 100.0 nM 7.0 Anticytokinin activity against Nicotiana tabacum 29273417
Nicotiana tabacum IC50 = 730.0 nM 6.14 Toxicity in Nicotiana tabacum 29273417

Literature References

PubMed DOI Target Context # Activities
29273417 10.1016/j.bmc.2017.10.012 Nicotiana tabacum 2

Data from ChEMBL 36 via Core Engine