Compound Detail
CHEMBL420860
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Basic Information
| ChEMBL ID | CHEMBL420860 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DJQCAHKSIIELAB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 2/cyclin A CHEMBL2094128 | IC50 | 4.48 | 4.48 | 33000.0 | 1 |
| Cyclin-dependent kinase 1/cyclin B1 CHEMBL1907602 | IC50 | 4.44 | 4.44 | 36000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 2/cyclin A | IC50 | = | 33000.0 | nM | 4.48 | Inhibition of human Cyclin-dependent kinase 2-cyclin A | 12139449 |
| Cyclin-dependent kinase 1/cyclin B1 | IC50 | = | 36000.0 | nM | 4.44 | Inhibition of starfish oocyte (Marthasteria glacialis) Cyclin-dependent kinase 1... | 12139449 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12139449 | 10.1021/jm020056z | Cyclin-dependent kinase 1/cyclin B1 | 1 |
| 12139449 | 10.1021/jm020056z | Cyclin-dependent kinase 2/cyclin A | 1 |
Data from ChEMBL 36 via Core Engine