Compound Detail
CHEMBL4209583
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Basic Information
| ChEMBL ID | CHEMBL4209583 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HCZOMSNBQCWQJO-UHFFFAOYSA-N |
3
Targets
7
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
413.4
MW (Da)
4.14
ALogP
6
HBA
3
HBD
108.5
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.17
Ki 1 meas. best 9.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TGF-beta receptor type-1 CHEMBL4439 | Ki | 9.82 | 9.82 | 0.1 | 1 |
| TGF-beta receptor type-1 CHEMBL4439 | IC50 | 9.17 | 8.6967 | 0.7 | 3 |
| Unchecked CHEMBL612545 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| TGF-beta receptor type-2 CHEMBL4267 | IC50 | 6.03 | 5.665 | 940.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TGF-beta receptor type-1 | Ki | = | 0.15 | nM | 9.82 | Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect ce... | 29422332 |
| TGF-beta receptor type-1 | IC50 | = | 0.67 | nM | 9.17 | Biological Assays: Assays are conducted in 1536-well plates and 2 mL reactions a... | - |
| TGF-beta receptor type-1 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of human His-tagged TGFbetaR1 T204D mutant expressed in Sf9 insect ce... | 29422332 |
| TGF-beta receptor type-1 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of TGFbetaR1 in human primary T-cells assessed as TGFbeta-stimulated ... | 29422332 |
| Unchecked | IC50 | = | 43.0 | nM | 7.37 | Inhibition of TGFbetaR1 in mink Mv1Lu cells assessed as TGFbeta-stimulated PSMAD... | 29422332 |
| TGF-beta receptor type-2 | IC50 | = | 940.0 | nM | 6.03 | Inhibition of wild type His-tagged TGFbetaR2 (unknown origin) after 1 hr by HTRF... | 29422332 |
| TGF-beta receptor type-2 | IC50 | = | 5000.0 | nM | 5.3 | Biological Assays: Assays are conducted in 1536-well plates and 2 mL reactions a... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29422332 | 10.1016/j.bmc.2018.01.014 | TGF-beta receptor type-1 | 3 |
| 29422332 | 10.1016/j.bmc.2018.01.014 | ADMET | 3 |
| 29422332 | 10.1016/j.bmc.2018.01.014 | Unchecked | 1 |
| 29422332 | 10.1016/j.bmc.2018.01.014 | TGF-beta receptor type-2 | 1 |
Data from ChEMBL 36 via Core Engine