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Compound Detail

CHEMBL4213277

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CC[N+]1=C(/C=C/C=C/C=C2/N(CCCCCC(=O)NCCCCCCNc3nc4c(N)ncnc4n3[C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c3ccc(S(=O)(=O)O)cc3C2(C)C)C(C)(C)c2cc(S(=O)(=O)[O-])ccc21

Basic Information

ChEMBL ID CHEMBL4213277
Phase Preclinical
Structure Type MOL
InChI Key OVZDEIWNVVEXJW-NQIMOJJLSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1260.2
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C49H68N9O20P3S2
MW 1260.18

Activity Summary

Kd 1 meas. best 5.64

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 5.64 5.64 2300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 2300.0 nM 5.64 Displacement of Cy5-labelled (position-4) ATP from human HSP70 expressed in Esch... 29042222

Literature References

PubMed DOI Target Context # Activities
29042222 10.1016/j.bmc.2017.10.003 Unchecked 1

Data from ChEMBL 36 via Core Engine