Compound Detail
CHEMBL4214699
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Basic Information
| ChEMBL ID | CHEMBL4214699 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QUKABWAMCFBWDF-UHFFFAOYSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
451.5
MW (Da)
2.98
ALogP
8
HBA
3
HBD
135.3
PSA (Ų)
0.28
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | IC50 | 8.52 | 8.52 | 3.0 | 2 |
| Histone deacetylase 6 CHEMBL1865 | IC50 | 6.78 | 6.78 | 168.0 | 1 |
| Histone deacetylase 1 CHEMBL325 | IC50 | 5.65 | 5.65 | 2230.0 | 1 |
| Histone deacetylase 2 CHEMBL1937 | IC50 | 4.76 | 4.76 | 17500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of full length human recombinant N-terminal GST-tagged PDE5A1 express... | 29549837 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | IC50 | = | 3.0 | nM | 8.52 | Inhibition of PDE5 (unknown origin) | 30245400 |
| Histone deacetylase 6 | IC50 | = | 168.0 | nM | 6.78 | Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expresse... | 29549837 |
| Histone deacetylase 1 | IC50 | = | 2230.0 | nM | 5.65 | Inhibition of full length human recombinant C-terminal FLAG/His-tagged HDAC1 exp... | 29549837 |
| Histone deacetylase 2 | IC50 | = | 17500.0 | nM | 4.76 | Inhibition of full length human recombinant C-terminal His-tagged HDAC2 expresse... | 29549837 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29549837 | 10.1016/j.ejmech.2018.03.005 | Histone deacetylase 1 | 1 |
| 29549837 | 10.1016/j.ejmech.2018.03.005 | Histone deacetylase 2 | 1 |
| 29549837 | 10.1016/j.ejmech.2018.03.005 | Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) | 1 |
| 29549837 | 10.1016/j.ejmech.2018.03.005 | Histone deacetylase 6 | 1 |
| 29549837 | 10.1016/j.ejmech.2018.03.005 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
| 30245400 | 10.1016/j.ejmech.2018.09.028 | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine