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Compound Detail

CHEMBL421489

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COc1ccc(CCNC[C@@H](O)COc2cccc3[nH]c(O)nc23)cc1

Basic Information

ChEMBL ID CHEMBL421489
Phase Preclinical
Structure Type MOL
InChI Key JRMZXBLICUKXNC-CQSZACIVSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

357.4
MW (Da)
1.85
ALogP
6
HBA
4
HBD
99.6
PSA (Ų)
0.44
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23N3O4
MW 357.41
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.57

Activity Summary

EC50 1 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 5.66 5.66 2200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Beta-3 adrenergic receptor EC50 = 2200.0 nM 5.66 Agonist efficacy for human Beta-3 adrenergic receptor expressed in chinese hamst... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(96)00603-8 Beta-3 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine