Assay Detail
Functional
CHEMBL650700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist efficacy for human Beta-3 adrenergic receptor expressed in chinese hamster ovary cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.97 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62091 | — | — | 1 | 6.92 |
| CHEMBL72396 | — | — | 1 | 6.54 |
| CHEMBL305808 | — | — | 1 | 6.40 |
| CHEMBL70399 | — | — | 1 | 6.25 |
| CHEMBL302370 | — | — | 1 | 6.09 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 6.00 |
| CHEMBL70557 | — | — | 1 | 6.00 |
| CHEMBL73770 | — | — | 1 | 5.96 |
| CHEMBL70403 | — | — | 1 | 5.70 |
| CHEMBL420746 | CGP-12177 | — | 1 | 5.70 |
| CHEMBL421489 | — | — | 1 | 5.66 |
| CHEMBL72706 | — | — | 1 | 5.33 |
| CHEMBL306838 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62091 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL72396 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL305808 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL70399 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL302370 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL70557 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL73770 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL70403 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL420746 | CGP-12177 | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL421489 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL72706 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL306838 | — | EC50 | = | 7900.0 | nM | 5.10 |