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Compound Detail

CHEMBL4215453

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CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)CN)C(=O)N[C@@H](CSSC[C@@H](C(N)=O)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N2

Basic Information

ChEMBL ID CHEMBL4215453
Phase Preclinical
Structure Type MOL
InChI Key YDMCKCUHYZRPDS-FYHDBFLGSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

1565.9
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C64H96N18O18S5
MW 1565.92

Activity Summary

IC50 2 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuronal acetylcholine receptor; alpha3/beta4
CHEMBL1907593
IC50 8.1 8.1 7.9 1
Nicotinic acetylcholine receptor alpha6/alpha3/beta4
CHEMBL3137276
IC50 7.64 7.64 23.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30252466 10.1021/acs.jmedchem.8b00967 Nicotinic acetylcholine receptor alpha6/alpha3/beta4 1
30252466 10.1021/acs.jmedchem.8b00967 Neuronal acetylcholine receptor; alpha3/beta4 1
30252466 10.1021/acs.jmedchem.8b00967 Unchecked 1

Data from ChEMBL 36 via Core Engine