Compound Detail
CHEMBL4218055
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Cn1c(=O)c2c(nc(NCCc3ccccc3)n2CCCC(=O)N/N=C/c2ccccc2O)n(C)c1=O
Basic Information
| ChEMBL ID | CHEMBL4218055 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XJVSPEKDSQVFJO-OGLMXYFKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
503.6
MW (Da)
1.72
ALogP
10
HBA
3
HBD
135.5
PSA (Ų)
0.22
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A CHEMBL3012 | IC50 | 5.14 | 5.14 | 7300.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 4.57 | 4.57 | 26900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | IC50 | = | 7300.0 | nM | 5.14 | Inhibition of human GST-tagged PDE7A expressed in baculovirus infected Sf9 insec... | 29407965 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 26900.0 | nM | 4.57 | Inhibition of human GST-tagged PDE4B expressed in baculovirus infected Sf9 insec... | 29407965 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29407965 | 10.1016/j.ejmech.2018.01.068 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
| 29407965 | 10.1016/j.ejmech.2018.01.068 | High affinity 3',5'-cyclic-AMP phosphodiesterase 7A | 1 |
Data from ChEMBL 36 via Core Engine