Compound Detail
CHEMBL4218727
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Basic Information
| ChEMBL ID | CHEMBL4218727 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KULAYTGUTXCHSV-JOCHJYFZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
452.6
MW (Da)
3.61
ALogP
5
HBA
4
HBD
107.1
PSA (Ų)
0.35
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1.4 | nM | 8.85 | Inhibition of FTase isolated from human Burkitt's lymphoma cells assessed as dec... | 28505447 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28505447 | 10.1021/acs.jmedchem.6b01817 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine