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Compound Detail

CHEMBL4218835

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C[C@H](/C=C\C/C=C\C/C=C\CCCC(=O)NC1CC1)/C=C\CCCCCN=C=S

Basic Information

ChEMBL ID CHEMBL4218835
Phase Preclinical
Structure Type MOL
InChI Key BARJBEHYTMHBBK-ZUIPPAGJSA-N
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

414.7
MW (Da)
6.74
ALogP
3
HBA
1
HBD
41.5
PSA (Ų)
0.12
QED
1
Ro5 Violations
17
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H38N2OS
MW 414.66
Aromatic Rings 0
Heavy Atoms 29
NP-Likeness 0.74

Activity Summary

Ki 4 meas. best 7.81

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 1
CHEMBL3571
Ki 7.81 7.75 15.6 2
Cannabinoid receptor 2
CHEMBL253
Ki 7.66 7.66 22.1 1
Cannabinoid receptor 2
CHEMBL5373
Ki 7.32 7.32 47.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30196704 10.1021/acs.jmedchem.8b00611 Cannabinoid receptor 1 2
30196704 10.1021/acs.jmedchem.8b00611 Cannabinoid receptor 2 2

Data from ChEMBL 36 via Core Engine