Compound Detail
CHEMBL4227835
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C=CC(=O)NCCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N1CCN(c2cccc(I)n2)CC1
Basic Information
| ChEMBL ID | CHEMBL4227835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AEJRXPOAWTVMBU-NRFANRHFSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
589.5
MW (Da)
2.53
ALogP
5
HBA
2
HBD
94.6
PSA (Ų)
0.18
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.85
Ki 1 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein-glutamine gamma-glutamyltransferase CHEMBL2730 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Protein-glutamine gamma-glutamyltransferase CHEMBL2730 | Ki | 5.54 | 5.54 | 2920.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-glutamine gamma-glutamyltransferase | IC50 | = | 140.0 | nM | 6.85 | Inhibition of human TGase 2 using R-I-Cad/DMC as substrate preincubated for 5 mi... | 29664627 |
| Protein-glutamine gamma-glutamyltransferase | Ki | = | 2920.0 | nM | 5.54 | Reversible inhibition of human TGase 2 using Z-Glu(HMC)-Gly-OH as substrate meas... | 29664627 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29664627 | 10.1021/acs.jmedchem.8b00286 | Protein-glutamine gamma-glutamyltransferase | 3 |
Data from ChEMBL 36 via Core Engine