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Compound Detail

CHEMBL42336

METHIONINE
🧪 Phase III
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🧪 Phase III
CSCC[C@H](N)C(=O)O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL42336
Name METHIONINE
Phase Phase III
Structure Type MOL
InChI Key FFEARJCKVFRZRR-BYPYZUCNSA-N
Therapeutic ✓ Yes

Known Names

L-methionine Methionine Metionina NSC-22946
1
Targets
5
Activities
3
Assay Types
0
PK Parameters
20
Publications
4
Known Names
11
Indications

Molecular Properties

149.2
MW (Da)
0.15
ALogP
3
HBA
2
HBD
63.3
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product
USAN Year 1980

Extended Properties

Molecular Formula C5H11NO2S
MW 149.21
Aromatic Rings 0
Heavy Atoms 9
NP-Likeness 0.34

Indications

Hearing Loss, Noise-Induced Jaundice, Obstructive Craniopharyngioma Ependymoma Glioblastoma Hepatitis C, Chronic Hot Flashes Rhabdomyosarcoma Abdominal Pain Carcinoma, Hepatocellular Pulmonary Alveolar Proteinosis

ATC Classification

V03AB26
methionine
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS

Activity Summary

IC50 2 meas.
Ki 2 meas. best 4.21
EC50 1 meas.

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
S-ribosylhomocysteine lyase
CHEMBL5171
 Ki 4.21 4.21 61000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
S-ribosylhomocysteine lyase Ki = 61000.0 nM 4.21 Inhibition of cobalt substituted Bacillus subtilis LuxS 16686542

Literature References

PubMed DOI Target Context # Activities
10803956 10.1271/bbb.64.577 Oryza sativa 14
15646539 10.1016/s0399-8320(04)95062-2 Unchecked 11
15646539 10.1016/s0399-8320(04)95062-2 NON-PROTEIN TARGET 8
- 10.6019/CHEMBL4808148 Histone deacetylase 6 6
6677713 10.1021/np50030a003 Hepatocyte 6
16686542 10.1021/jm060047g S-ribosylhomocysteine lyase 5
- 10.6019/CHEMBL4495565 SARS-CoV-2 4
18059261 10.1038/nchembio.2007.56 Unchecked 4
3755757 10.1021/jm00159a030 S-adenosylmethionine synthetase (MAT 1 and MAT 2) 3
20014752 10.1021/tx900326k Hepatotoxicity 3
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 2
722714 10.1021/jm00208a011 Unchecked 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
30048132 10.1021/acs.jmedchem.8b01007 Large neutral amino acids transporter small subunit 1 2
3486976 10.1021/jm00156a022 ADMET 2
27624080 10.1016/j.bmcl.2016.09.001 Large neutral amino acids transporter small subunit 1 2
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
3755757 10.1021/jm00159a030 Unchecked 2
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2

Data from ChEMBL 36 via Core Engine