Assay Detail
Binding
CHEMBL861693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cobalt substituted Bacillus subtilis LuxS
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
S-ribosylhomocysteine lyase (CHEMBL5171) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.02 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208091 | — | — | 1 | 6.43 |
| CHEMBL207406 | — | — | 1 | 6.14 |
| CHEMBL42336 | METHIONINE | 3.0 | 1 | 4.21 |
| CHEMBL206725 | — | — | 1 | 4.17 |
| CHEMBL383729 | — | — | 1 | 4.16 |
| CHEMBL438441 | — | — | 1 | - |
| CHEMBL379182 | — | — | 1 | - |
| CHEMBL206556 | — | — | 1 | - |
| CHEMBL117442 | — | — | 1 | - |
| CHEMBL208235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208091 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL207406 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL42336 | METHIONINE | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL206725 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL383729 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL438441 | — | Ki | = | 473000.0 | nM | - |
| CHEMBL379182 | — | Ki | = | 155000.0 | nM | - |
| CHEMBL206556 | — | Ki | = | 132000.0 | nM | - |
| CHEMBL117442 | — | Ki | = | 156000.0 | nM | - |
| CHEMBL208235 | — | Ki | - | — | - |