Compound Detail
CHEMBL4238931
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Basic Information
| ChEMBL ID | CHEMBL4238931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGPGMXDMKMDYLN-JTQLQIEISA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
272.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 7.69 | 7.69 | 20.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 20.44 | nM | 7.69 | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-L... | 29934218 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29934218 | 10.1016/j.bmc.2018.06.020 | Proteasome Macropain subunit MB1 | 1 |
Data from ChEMBL 36 via Core Engine