Compound Detail
CHEMBL4244280
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
O=S(=O)(c1cncc2ccccc12)N1CCCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1
Basic Information
| ChEMBL ID | CHEMBL4244280 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LWDHUYPVZPEUAM-HSZRJFAPSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
520.7
MW (Da)
5.21
ALogP
6
HBA
0
HBD
56.8
PSA (Ų)
0.35
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A CHEMBL214 | Ki | 7.92 | 7.92 | 12.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 7.64 | 7.64 | 23.0 | 1 |
| 5-hydroxytryptamine receptor 7 CHEMBL3155 | Ki | 7.5 | 7.5 | 32.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 7.19 | 7.19 | 64.0 | 1 |
| 5-hydroxytryptamine receptor 6 CHEMBL3371 | Ki | 6.66 | 6.66 | 221.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Ki | = | 12.0 | nM | 7.92 | Displacement of [3H]-8-OH-DPAT from human 5-HT1AR expressed in HEK293 cell membr... | 29407591 |
| D(2) dopamine receptor | Ki | = | 23.0 | nM | 7.64 | Displacement of [3H]-raclopride from human D2LR expressed in HEK293 cell membran... | 29407591 |
| 5-hydroxytryptamine receptor 7 | Ki | = | 32.0 | nM | 7.5 | Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes a... | 29407591 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 64.0 | nM | 7.19 | Displacement of [3H]-ketanserin from human 5-HT2AR expressed in CHO-K1 cell memb... | 29407591 |
| 5-hydroxytryptamine receptor 6 | Ki | = | 221.0 | nM | 6.66 | Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cell membranes af... | 29407591 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29407591 | 10.1016/j.ejmech.2018.01.002 | Unchecked | 1 |
| 29407591 | 10.1016/j.ejmech.2018.01.002 | D(2) dopamine receptor | 1 |
| 29407591 | 10.1016/j.ejmech.2018.01.002 | 5-hydroxytryptamine receptor 7 | 1 |
| 29407591 | 10.1016/j.ejmech.2018.01.002 | 5-hydroxytryptamine receptor 6 | 1 |
| 29407591 | 10.1016/j.ejmech.2018.01.002 | 5-hydroxytryptamine receptor 2A | 1 |
| 29407591 | 10.1016/j.ejmech.2018.01.002 | 5-hydroxytryptamine receptor 1A | 1 |
Data from ChEMBL 36 via Core Engine