Compound Detail
CHEMBL424809
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Basic Information
| ChEMBL ID | CHEMBL424809 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XFYWEUWLOVVBSJ-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
371.3
MW (Da)
3.67
ALogP
3
HBA
3
HBD
74.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C beta type CHEMBL3045 | IC50 | 5.84 | 5.8367 | 1450.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C beta type | IC50 | = | 1450.0 | nM | 5.84 | Inhibitory concentration against recombinant human Protein kinase C beta 2 | 15380221 |
| Protein kinase C beta type | IC50 | = | 1450.0 | nM | 5.84 | Inhibition of PKCbeta2 (unknown origin) | - |
| Protein kinase C beta type | IC50 | = | 1479.11 | nM | 5.83 | Inhibition of PKCbeta2 (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-010-9439-6 | Protein kinase C beta type | 2 |
| 15380221 | 10.1016/j.bmcl.2004.07.061 | Protein kinase C beta type | 1 |
Data from ChEMBL 36 via Core Engine