Compound Detail
CHEMBL425222
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Basic Information
| ChEMBL ID | CHEMBL425222 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WIJLEHSGJSCEDR-SJCJKPOMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
314.4
MW (Da)
2.82
ALogP
4
HBA
1
HBD
54.6
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 7.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL4317 | Kd | 7.15 | 7.15 | 70.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Kd | = | 70.79 | nM | 7.15 | Antagonism at 5HT4 receptor in rat tunica muscularis mucosa | 16451077 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16451077 | 10.1021/jm0509501 | 5-hydroxytryptamine receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine