Compound Detail
CHEMBL4278272
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CNC(=O)[C@H](C[C@]1(O)C(=O)Nc2ccccc21)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)OC(C)(C)C
Basic Information
| ChEMBL ID | CHEMBL4278272 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VJAVWKXQEXLPKK-BGCNNDQISA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
673.8
MW (Da)
2.67
ALogP
8
HBA
6
HBD
184.2
PSA (Ų)
0.16
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome subunit beta type-10 CHEMBL3317334 | IC50 | 4.1 | 4.1 | 79000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.1 | 4.1 | 79000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome subunit beta type-10 | IC50 | = | 79000.0 | nM | 4.1 | Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate in... | 29339252 |
| Unchecked | IC50 | = | 79000.0 | nM | 4.1 | Inhibition of yeast 20S constitutive proteasome beta-5 | 29339252 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29339252 | 10.1016/j.ejmech.2018.01.013 | Proteasome subunit beta type-10 | 2 |
| 29339252 | 10.1016/j.ejmech.2018.01.013 | Unchecked | 2 |
| 29339252 | 10.1016/j.ejmech.2018.01.013 | Proteasome component C5 | 1 |
| 29339252 | 10.1016/j.ejmech.2018.01.013 | Proteasome subunit beta type-9 | 1 |
| 29339252 | 10.1016/j.ejmech.2018.01.013 | Proteasome Macropain subunit | 1 |
Data from ChEMBL 36 via Core Engine