Compound Detail
CHEMBL4279564
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc(O)c([C@@H]2O[C@H](CO)[C@@H](F)[C@H](O)[C@H]2O)cc1Cc1cc2c(s1)CCN(C(=O)N1CCCC1)C2
Basic Information
| ChEMBL ID | CHEMBL4279564 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARQIZUIFNYWJJU-HFBCXCLPSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
520.6
MW (Da)
2.42
ALogP
7
HBA
4
HBD
113.7
PSA (Ų)
0.49
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 7.87 | 7.87 | 13.6 | 1 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 7.39 | 7.39 | 40.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 | IC50 | = | 13.6 | nM | 7.87 | Inhibition of human kidneyl SGLT2 expressed in CHOK1 cells assessed as reduction... | 30268701 |
| Sodium/glucose cotransporter 1 | IC50 | = | 40.4 | nM | 7.39 | Inhibition of human small intestinal SGLT1 expressed in CHOK1 cells assessed as ... | 30268701 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30268701 | 10.1016/j.bmcl.2018.09.025 | ADMET | 3 |
| 30268701 | 10.1016/j.bmcl.2018.09.025 | Sodium/glucose cotransporter 1 | 1 |
| 30268701 | 10.1016/j.bmcl.2018.09.025 | Sodium/glucose cotransporter 2 | 1 |
Data from ChEMBL 36 via Core Engine