Compound Detail
CHEMBL427991
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Basic Information
| ChEMBL ID | CHEMBL427991 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JZHILFCUIHARMU-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
271.2
MW (Da)
0.16
ALogP
7
HBA
3
HBD
169.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA... | 9379437 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9379437 | 10.1021/jm950028z | Glutamate receptor ionotropic, AMPA | 2 |
| 9544203 | 10.1021/jm970276q | Glutamate receptor ionotropic, AMPA | 1 |
| 9379437 | 10.1021/jm950028z | ADMET | 1 |
| 9379437 | 10.1021/jm950028z | Glutamate receptor ionotropic, kainate | 1 |
| 9379437 | 10.1021/jm950028z | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine