Assay Detail
Binding
CHEMBL697794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of specific binding of [3H]AMPA to Ionotropic glutamate receptor AMPA in rat brain membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.09 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | — | 1 | 7.89 |
| CHEMBL366588 | — | — | 1 | 6.92 |
| CHEMBL9790 | — | — | 1 | 6.27 |
| CHEMBL155265 | DNQX | — | 1 | 6.03 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.92 |
| CHEMBL366489 | — | — | 1 | 5.75 |
| CHEMBL108147 | — | — | 1 | 5.31 |
| CHEMBL427991 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276815 | (S)-AMPA | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL366588 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL9790 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL155265 | DNQX | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL366489 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL108147 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL427991 | — | IC50 | = | 25000.0 | nM | 4.60 |