Compound Detail
CHEMBL4282980
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4282980 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SFJREJRCVVEJQX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
303.3
MW (Da)
2.84
ALogP
5
HBA
3
HBD
92.9
PSA (Ų)
0.76
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 8.3 | 8.15 | 5.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 5.0 | nM | 8.3 | Inhibition of BRM/BRG1 mutant-dependant cell proliferation in human SKMEL5 cells... | 30339381 |
| Unchecked | EC50 | = | 10.0 | nM | 8.0 | Inhibition of BRM/BRG1 mutant in human NCI-H1299 cells assessed as reduction in ... | 30339381 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Unchecked | 2 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | No relevant target | 1 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | SBC-5 | 1 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Transcription activator BRG1 | 1 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Probable global transcription activator SNF2L2 | 1 |
Data from ChEMBL 36 via Core Engine