Assay Detail
Binding
CHEMBL4276243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRM/BRG1 mutant-dependant cell proliferation in human SKMEL5 cells after 6 days by celltiter-glo luminescent cell viability assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.58 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4295096 | — | — | 1 | 8.40 |
| CHEMBL4282980 | — | — | 1 | 8.30 |
| CHEMBL4293567 | — | — | 1 | 7.89 |
| CHEMBL4286345 | — | — | 1 | 7.89 |
| CHEMBL4278436 | — | — | 1 | 7.51 |
| CHEMBL4294655 | — | — | 1 | 6.89 |
| CHEMBL4286757 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4295096 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4282980 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4293567 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4286345 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4278436 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4294655 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4286757 | — | EC50 | = | 650.0 | nM | 6.19 |