Compound Detail
CHEMBL4293567
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Basic Information
| ChEMBL ID | CHEMBL4293567 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AVHFGSYJGSZHIC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
334.7
MW (Da)
3.27
ALogP
5
HBA
3
HBD
87.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 7.89 | 7.635 | 13.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 13.0 | nM | 7.89 | Inhibition of BRM/BRG1 mutant-dependant cell proliferation in human SKMEL5 cells... | 30339381 |
| Unchecked | EC50 | = | 42.0 | nM | 7.38 | Inhibition of BRM/BRG1 mutant in human NCI-H1299 cells assessed as reduction in ... | 30339381 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Unchecked | 2 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | SBC-5 | 1 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Transcription activator BRG1 | 1 |
| 30339381 | 10.1021/acs.jmedchem.8b01318 | Probable global transcription activator SNF2L2 | 1 |
Data from ChEMBL 36 via Core Engine