Compound Detail
CHEMBL4284218
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Basic Information
| ChEMBL ID | CHEMBL4284218 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GKJDOZCYKMQNHL-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
479.7
MW (Da)
5.16
ALogP
5
HBA
2
HBD
64.3
PSA (Ų)
0.42
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.96 | 6.625 | 110.0 | 2 |
| Sterol O-acyltransferase 1 CHEMBL2782 | IC50 | 6.55 | 6.55 | 280.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 110.0 | nM | 6.96 | Inhibition of ACAT in arterial homogenates isolated from 1% cholesterol fed New ... | 30433781 |
| Sterol O-acyltransferase 1 | IC50 | = | 280.0 | nM | 6.55 | Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-ch... | 30433781 |
| Unchecked | IC50 | = | 510.0 | nM | 6.29 | Inhibition of ACAT in New Zealand White rabbit intestinal microsomes assessed as... | 30433781 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30433781 | 10.1021/acs.jmedchem.8b01256 | Unchecked | 3 |
| 30433781 | 10.1021/acs.jmedchem.8b01256 | Sterol O-acyltransferase 1 | 1 |
Data from ChEMBL 36 via Core Engine