Compound Detail
CHEMBL4286674
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Basic Information
| ChEMBL ID | CHEMBL4286674 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JFCPDRJTGNEZRS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
272.3
MW (Da)
1.40
ALogP
5
HBA
2
HBD
80.0
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 2B CHEMBL3779760 | IC50 | 7.0 | 6.63 | 100.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 2B | IC50 | = | 100.0 | nM | 7.0 | Inhibition of recombinant human C-terminal FLAG-tagged FBXL10 (1 to 650 residues... | - |
| Lysine-specific demethylase 2B | IC50 | = | 550.0 | nM | 6.26 | FBXL10 Assay: The ability of test compounds to inhibit the activity of FBXL10 wa... | - |
Data from ChEMBL 36 via Core Engine