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Assay Detail

CHEMBL4257285

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human C-terminal FLAG-tagged FBXL10 (1 to 650 residues) expressed in baculovirus infected sf9 cells using H3K36me2-biotin peptide as substrate after 30 mins in presence of alpha-ketoglutaric acid by AlphaScreen assay
ChEMBL ↗
150
Total Activities
150
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Lysine-specific demethylase 2B (CHEMBL3779760) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Histone demethylase inhibitors
(2016)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 150 6.83 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4290028 — — 1 7.00
CHEMBL4290366 — — 1 7.00
CHEMBL4290020 — — 1 7.00
CHEMBL4294755 — — 1 7.00
CHEMBL4294432 — — 1 7.00
CHEMBL4283306 — — 1 7.00
CHEMBL4288414 — — 1 7.00
CHEMBL4279372 — — 1 7.00
CHEMBL4293359 — — 1 7.00
CHEMBL4283417 — — 1 7.00
CHEMBL4288025 — — 1 7.00
CHEMBL4286674 — — 1 7.00
CHEMBL4286314 — — 1 7.00
CHEMBL4291702 — — 1 7.00
CHEMBL4279284 — — 1 7.00
CHEMBL4278863 — — 1 7.00
CHEMBL4277960 — — 1 7.00
CHEMBL4283146 — — 1 7.00
CHEMBL4286705 — — 1 7.00
CHEMBL3787664 — — 1 7.00
CHEMBL4286418 — — 1 7.00
CHEMBL4285443 — — 1 7.00
CHEMBL4288145 — — 1 7.00
CHEMBL3786803 — — 1 7.00
CHEMBL4293936 — — 1 7.00
CHEMBL4284869 — — 1 7.00
CHEMBL4286983 — — 1 7.00
CHEMBL4288034 — — 1 7.00
CHEMBL4288406 — — 1 7.00
CHEMBL4292111 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4290366 — IC50 = 100.0 nM 7.00
CHEMBL4292111 — IC50 = 100.0 nM 7.00
CHEMBL4288406 — IC50 = 100.0 nM 7.00
CHEMBL4278863 — IC50 = 100.0 nM 7.00
CHEMBL4288034 — IC50 = 100.0 nM 7.00
CHEMBL4286983 — IC50 = 100.0 nM 7.00
CHEMBL3787664 — IC50 = 100.0 nM 7.00
CHEMBL4286418 — IC50 = 100.0 nM 7.00
CHEMBL4288145 — IC50 = 100.0 nM 7.00
CHEMBL3786803 — IC50 = 100.0 nM 7.00
CHEMBL4293936 — IC50 = 100.0 nM 7.00
CHEMBL4284869 — IC50 = 100.0 nM 7.00
CHEMBL4285443 — IC50 = 100.0 nM 7.00
CHEMBL4286705 — IC50 = 100.0 nM 7.00
CHEMBL4283146 — IC50 = 100.0 nM 7.00
CHEMBL4288414 — IC50 = 100.0 nM 7.00
CHEMBL4277960 — IC50 = 100.0 nM 7.00
CHEMBL4293359 — IC50 = 100.0 nM 7.00
CHEMBL4290020 — IC50 = 100.0 nM 7.00
CHEMBL4294755 — IC50 = 100.0 nM 7.00
CHEMBL4294432 — IC50 = 100.0 nM 7.00
CHEMBL4283306 — IC50 = 100.0 nM 7.00
CHEMBL4279372 — IC50 = 100.0 nM 7.00
CHEMBL4283417 — IC50 = 100.0 nM 7.00
CHEMBL4288025 — IC50 = 100.0 nM 7.00
CHEMBL4286674 — IC50 = 100.0 nM 7.00
CHEMBL4286314 — IC50 = 100.0 nM 7.00
CHEMBL4291702 — IC50 = 100.0 nM 7.00
CHEMBL4279284 — IC50 = 100.0 nM 7.00
CHEMBL4290028 — IC50 = 100.0 nM 7.00
CHEMBL4285770 — IC50 = 1000.0 nM 6.00
CHEMBL4285921 — IC50 = 1000.0 nM 6.00
CHEMBL4286299 — IC50 = 1000.0 nM 6.00
CHEMBL4289480 — IC50 = 1000.0 nM 6.00
CHEMBL4294777 — IC50 = 1000.0 nM 6.00
CHEMBL4287989 — IC50 = 1000.0 nM 6.00
CHEMBL4291057 — IC50 <= 100.0 nM -
CHEMBL4293159 — IC50 <= 100.0 nM -
CHEMBL4292153 — IC50 <= 100.0 nM -
CHEMBL4280440 — IC50 <= 100.0 nM -
CHEMBL4281614 — IC50 <= 100.0 nM -
CHEMBL4282658 — IC50 <= 100.0 nM -
CHEMBL4277801 — IC50 <= 100.0 nM -
CHEMBL4278827 — IC50 <= 100.0 nM -
CHEMBL4294639 — IC50 <= 100.0 nM -
CHEMBL4277136 — IC50 <= 100.0 nM -
CHEMBL4277523 — IC50 <= 100.0 nM -
CHEMBL4281241 — IC50 <= 100.0 nM -
CHEMBL4287370 — IC50 <= 100.0 nM -
CHEMBL4291787 — IC50 <= 100.0 nM -