Compound Detail
CHEMBL4287370
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Basic Information
| ChEMBL ID | CHEMBL4287370 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HQHTWKLZEQTHKQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
445.9
MW (Da)
4.83
ALogP
6
HBA
1
HBD
85.2
PSA (Ų)
0.40
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lysine-specific demethylase 4C CHEMBL6175 | IC50 | 6.0 | 5.63 | 1000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lysine-specific demethylase 4C | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of recombinant human N-terminal GST-tagged JMJD2C (2 to 372 residues)... | - |
| Lysine-specific demethylase 4C | IC50 | = | 5500.0 | nM | 5.26 | JMJD2C Assay: The ability of test compounds to inhibit the activity of JMJD2C wa... | - |
Data from ChEMBL 36 via Core Engine