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Compound Detail

CHEMBL4297378

DURLOBACTAM SODIUM
💊 Approved Drug
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💊 Approved Drug
CC1=C[C@@H]2CN(C(=O)N2OS(=O)(=O)[O-])[C@@H]1C(N)=O.[Na+]
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4297378
Name DURLOBACTAM SODIUM
Phase Approved
Structure Type MOL
InChI Key WHHNOICWPZIYKI-IBTYICNHSA-M
Parent Compound CHEMBL4298137
Active Moiety CHEMBL4298137

Known Names

Durlobactam sodium Durlobactam sodium component of xacduro ETX-2514 ETX-2514 SODIUM Etx2514 ETX2514 sodium
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
6
Known Names
2
Indications
4
Mechanisms

Molecular Properties

277.3
MW (Da)
-1.36
ALogP
5
HBA
2
HBD
130.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2023
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Parenteral
USAN Stem -bactam
USAN Year 2019

Extended Properties

Molecular Formula C8H10N3NaO6S
MW 299.24
Aromatic Rings 0
Heavy Atoms 18
NP-Likeness 0.17

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Beta-lactamase inhibitor INHIBITOR Beta-lactamase ✓ ✓
Beta-lactamase inhibitor INHIBITOR Beta-lactamase ✓ ✓
Beta-lactamase inhibitor INHIBITOR Beta-lactamase ✓ ✓
Beta-lactamase inhibitor INHIBITOR Beta-lactamase ✓ ✓

Indications

Bacterial Infections Infections

Literature References

PubMed DOI Target Context # Activities
31663735 10.1021/acs.jmedchem.9b01279 Unchecked 5

Data from ChEMBL 36 via Core Engine