Compound Detail
CHEMBL4297527
REVAMILAST 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4297527 |
| Name | REVAMILAST |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IXQHNBONEVULTL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
1
Known Names
2
Indications
1
Mechanisms
Molecular Properties
440.2
MW (Da)
4.77
ALogP
5
HBA
1
HBD
91.3
PSA (Ų)
0.36
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Phosphodiesterase 4 inhibitor | INHIBITOR | Phosphodiesterase 4 | ✓ | ✓ |
Indications
Arthritis, Rheumatoid Asthma
Activity Summary
IC50 2 meas. best 8.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 8.57 | 8.57 | 2.7 | 1 |
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 2.7 | nM | 8.57 | Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubate... | - |
| Phosphodiesterase 4 | IC50 | = | 3.0 | nM | 8.52 | Inhibition of PDE4 (unknown origin) | 32255344 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32255344 | 10.1021/acs.jmedchem.9b02170 | Phosphodiesterase 4 | 1 |
Data from ChEMBL 36 via Core Engine