Assay Detail
Binding
CHEMBL4419182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubated for 30 mins by scintillation counting method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
FMO3 inhibitors for treating pain
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.65 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 10.70 |
| CHEMBL193240 | ROFLUMILAST | 4.0 | 1 | 9.17 |
| CHEMBL4474098 | — | — | 1 | 8.68 |
| CHEMBL323312 | — | — | 1 | 8.62 |
| CHEMBL4297527 | REVAMILAST | 2.0 | 1 | 8.57 |
| CHEMBL4568146 | ELBIMILAST | 1.0 | 1 | 8.46 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.96 |
| CHEMBL2104505 | — | — | 1 | 7.52 |
| CHEMBL332750 | TETOMILAST | 3.0 | 1 | 7.16 |
| CHEMBL4297520 | OGLEMILAST | 2.0 | 1 | 6.78 |
| CHEMBL362652 | — | — | 1 | 6.70 |
| CHEMBL313842 | ZARDAVERINE | 2.0 | 1 | 6.41 |
| CHEMBL404216 | TOFISOPAM | 2.0 | 1 | 6.05 |
| CHEMBL590754 | FILAMINAST | 2.0 | 1 | 6.00 |
| CHEMBL603830 | DAXALIPRAM | 2.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL193240 | ROFLUMILAST | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL4474098 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL323312 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4297527 | REVAMILAST | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4568146 | ELBIMILAST | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2104505 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL332750 | TETOMILAST | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4297520 | OGLEMILAST | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL362652 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL313842 | ZARDAVERINE | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL404216 | TOFISOPAM | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL590754 | FILAMINAST | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL603830 | DAXALIPRAM | IC50 | = | 1100.0 | nM | 5.96 |