Compound Detail
CHEMBL590754
FILAMINAST 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL590754 |
| Name | FILAMINAST |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | STTRYQAGHGJXJJ-LICLKQGHSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
4
Known Names
Molecular Properties
292.3
MW (Da)
2.84
ALogP
5
HBA
1
HBD
83.1
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 3 meas. best 6.02
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 6.02 | 6.02 | 960.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 6.02 | 6.02 | 960.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 960.0 | nM | 6.02 | Inhibition of human MAPK p38alpha | 20188577 |
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 960.0 | nM | 6.02 | Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia c... | 26908025 |
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubate... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20188577 | 10.1016/j.bmc.2010.01.070 | Mitogen-activated protein kinase 14 | 1 |
| 26908025 | 10.1021/acs.jmedchem.5b01813 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine