Compound Detail
CHEMBL4474098
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Basic Information
| ChEMBL ID | CHEMBL4474098 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DQXFOLCDYKWSIT-GNAFDRTKSA-N |
| Parent Compound | CHEMBL32442 |
| Active Moiety | CHEMBL32442 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
373.5
MW (Da)
5.79
ALogP
3
HBA
0
HBD
31.4
PSA (Ų)
0.53
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D CHEMBL288 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4D | IC50 | = | 2.1 | nM | 8.68 | Inhibition of human PDE4D catalytic domain using [3H]-cAMP or [3H]-cGMP incubate... | - |
Data from ChEMBL 36 via Core Engine