Compound Detail
CHEMBL4303525
OMAVELOXOLONE 💊 Approved Drug
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
💊 Approved Drug
CC1(C)CC[C@]2(NC(=O)C(C)(F)F)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]5(C)C=C(C#N)C(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1
Basic Information
| ChEMBL ID | CHEMBL4303525 |
| Name | OMAVELOXOLONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | RJCWBNBKOKFWNY-IDPLTSGASA-N |
| Therapeutic | ✓ Yes |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
5
Known Names
4
Indications
1
Mechanisms
Molecular Properties
554.7
MW (Da)
6.73
ALogP
4
HBA
1
HBD
87.0
PSA (Ų)
0.41
QED
2
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2023 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Nuclear factor erythroid 2-related factor 2 activator | ACTIVATOR | Nuclear factor erythroid 2-related factor 2 | ✓ | ✓ |
Indications
Friedreich Ataxia Breast Neoplasms Liver Diseases Melanoma
ATC Classification
N07XX25
omaveloxolone
Level 1: NERVOUS SYSTEM
Level 2: OTHER NERVOUS SYSTEM DRUGS
Activity Summary
EC50 2 meas. best 5.85
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HT-29 | EC50 | = | 1410.0 | nM | 5.85 | Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalph... | 33248849 |
| L929 | EC50 | = | 5250.0 | nM | 5.28 | Anti-necroptotic activity in mouse L929 cells assessed as inhibition of TNFalpha... | 33248849 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 33248849 | 10.1016/j.ejmech.2020.113030 | HT-29 | 1 |
| 33248849 | 10.1016/j.ejmech.2020.113030 | L929 | 1 |
Data from ChEMBL 36 via Core Engine