Compound Detail
CHEMBL431818
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Basic Information
| ChEMBL ID | CHEMBL431818 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GITRKILOUAEMSZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
342.4
MW (Da)
3.46
ALogP
7
HBA
0
HBD
71.9
PSA (Ų)
0.68
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL4125 | IC50 | 6.24 | 6.24 | 570.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 570.0 | nM | 6.24 | Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(97)10117-2 | Platelet-derived growth factor receptor beta | 1 |
| - | 10.1016/S0960-894X(97)10117-2 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine