Compound Detail
CHEMBL441396
NEUROPEPTIDE Y(NPY) Enter ChEMBL ID:
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CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
Basic Information
| ChEMBL ID | CHEMBL441396 |
| Name | NEUROPEPTIDE Y(NPY) |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | BPGXUIVWLQTVLZ-OFGSCBOVSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
4254.7
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.52
IC50 1 meas. best 9.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | Ki | 9.52 | 9.52 | 0.3 | 1 |
| Neuropeptide Y receptor type 2 CHEMBL3309 | IC50 | 9.35 | 9.35 | 0.5 | 1 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | Ki | 8.7 | 8.7 | 2.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 | Ki | = | 0.3 | nM | 9.52 | Tested against neuropeptide Y2 receptors using SK-N-BE2 human neuroblastoma cell... | 8426366 |
| Neuropeptide Y receptor type 2 | IC50 | = | 0.45 | nM | 9.35 | 50% displacement of specifically bound [3H]NPY2 from rat brain membranes. | 7707318 |
| Neuropeptide Y receptor type 1 | Ki | = | 2.0 | nM | 8.7 | Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells | 8426366 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2918505 | 10.1021/jm00123a014 | Rattus norvegicus | 1 |
| 7707318 | 10.1021/jm00007a012 | Neuropeptide Y receptor type 2 | 1 |
| 7707318 | 10.1021/jm00007a012 | HEL | 1 |
| 8426366 | 10.1021/jm00055a010 | Neuropeptide Y receptor type 1 | 1 |
| 8426366 | 10.1021/jm00055a010 | Neuropeptide Y receptor type 2 | 1 |
Data from ChEMBL 36 via Core Engine