Compound Detail
CHEMBL4440813
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Basic Information
| ChEMBL ID | CHEMBL4440813 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AOXMXKZZJGQNES-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
360.4
MW (Da)
4.20
ALogP
5
HBA
0
HBD
52.8
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ephrin type-B receptor 4 CHEMBL5147 | IC50 | 6.57 | 6.57 | 266.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ephrin type-B receptor 4 | IC50 | = | 266.77 | nM | 6.57 | Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo reagent based lumine... | 30503935 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Vascular endothelial growth factor receptor 2 | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Angiopoietin-1 receptor | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | Ephrin type-B receptor 4 | 1 |
| 30503935 | 10.1016/j.ejmech.2018.11.042 | EA.hy 926 | 1 |
Data from ChEMBL 36 via Core Engine