Assay Detail
Binding
CHEMBL4330410
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Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo reagent based luminescent assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.11 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.66 |
| CHEMBL4519953 | — | — | 1 | 9.36 |
| CHEMBL4441465 | — | — | 1 | 8.52 |
| CHEMBL4452256 | — | — | 1 | 7.54 |
| CHEMBL4454065 | — | — | 1 | 7.01 |
| CHEMBL4440813 | — | — | 1 | 6.57 |
| CHEMBL4470400 | — | — | 1 | - |
| CHEMBL4456856 | — | — | 1 | - |
| CHEMBL4443204 | — | — | 1 | - |
| CHEMBL4449321 | — | — | 1 | - |
| CHEMBL4570075 | — | — | 1 | - |
| CHEMBL4449700 | — | — | 1 | - |
| CHEMBL4556134 | — | — | 1 | - |
| CHEMBL4556899 | — | — | 1 | - |
| CHEMBL4447552 | — | — | 1 | - |
| CHEMBL4473253 | — | — | 1 | - |
| CHEMBL4528844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4519953 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4441465 | — | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL4452256 | — | IC50 | = | 28.68 | nM | 7.54 |
| CHEMBL4454065 | — | IC50 | = | 96.86 | nM | 7.01 |
| CHEMBL4440813 | — | IC50 | = | 266.77 | nM | 6.57 |
| CHEMBL4470400 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4456856 | — | IC50 | - | — | - | |
| CHEMBL4443204 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4449321 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4570075 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4449700 | — | IC50 | - | — | - | |
| CHEMBL4556134 | — | IC50 | - | — | - | |
| CHEMBL4556899 | — | IC50 | - | — | - | |
| CHEMBL4447552 | — | IC50 | - | — | - | |
| CHEMBL4473253 | — | IC50 | - | — | - | |
| CHEMBL4528844 | — | IC50 | > | 1000.0 | nM | - |