Compound Detail
CHEMBL4447536
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Basic Information
| ChEMBL ID | CHEMBL4447536 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CQXJRHUVXHVCBE-GOSISDBHSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
368.5
MW (Da)
2.11
ALogP
4
HBA
1
HBD
76.4
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 30 CHEMBL4523357 | IC50 | 9.26 | 8.13 | 0.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase 30 | IC50 | = | 0.55 | nM | 9.26 | Biochemical Assay: Dilution plates were prepared at 21 times the final concentra... | - |
| Ubiquitin carboxyl-terminal hydrolase 30 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of untagged human USP30 catalytic domain (57 to 517 residues) express... | - |
Data from ChEMBL 36 via Core Engine