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Target Snapshot

CHEMBL4523357 Target Snapshot

Ubiquitin carboxyl-terminal hydrolase 30 · SINGLE PROTEIN · Homo sapiens

1,314Compounds
34Assays
0Approved Drugs
3,098.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q70CQ3. Use UniProt Q70CQ3 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q70CQ3 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ubiquitin carboxyl-terminal hydrolase 30 as ChEMBL target CHEMBL4523357, mapped to UniProt Q70CQ3. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ubiquitin carboxyl-terminal hydrolase 30
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4523357
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q70CQ3
Ubiquitin carboxyl-terminal hydrolase 30
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ubiquitin carboxyl-terminal hydrolase 30 is the right protein anchor across sources, using UniProt Q70CQ3 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUbiquitin carboxyl-terminal hydrolase 30
UniProt AccessionQ70CQ3
Component TypeProtein
Sequence Length517 aa

Ubiquitin carboxyl-terminal hydrolase 30

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ubiquitin carboxyl-terminal hydrolase 30, mapped to UniProt Q70CQ3. Sequence length is 517 aa.

Mapped IDQ70CQ3
Review nameUbiquitin carboxyl-terminal hydrolase 30
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC503,098.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4436246 9.26 IC50 0.55 Preclinical
CHEMBL4436843 9.26 IC50 0.55 Preclinical
CHEMBL4438257 9.26 IC50 0.55 Preclinical
CHEMBL4443079 9.26 IC50 0.55 Preclinical
CHEMBL4443544 9.26 IC50 0.55 Preclinical
CHEMBL4445549 9.26 IC50 0.55 Preclinical
CHEMBL4446824 9.26 IC50 0.55 Preclinical
CHEMBL4447536 9.26 IC50 0.55 Preclinical
CHEMBL4449295 9.26 IC50 0.55 Preclinical
CHEMBL4449473 9.26 IC50 0.55 Preclinical
Distribution

pChEMBL Value Distribution

362
5.0
50
5.5
1158
6.0
82
6.5
484
7.0
26
7.5
24
8.0
0
8.5
61
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

34
Total Assays
1,391
Tested Compounds
2
Assay Types
Binding — 33 assays, 1,391 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 26 1,002 6.2
assay format 6 389 6.9
cell-based format 1 0
Functional — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine