Compound Detail
CHEMBL4448290
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Basic Information
| ChEMBL ID | CHEMBL4448290 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WDHSKNJWBMQMET-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
200.2
MW (Da)
-1.04
ALogP
6
HBA
3
HBD
114.3
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 3 CHEMBL3504 | Ki | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 3 | Ki | = | 100000.0 | nM | 4.0 | Displacement of (RS)-[3H]AMPA from recombinant rat GluA3 expressed in baculoviru... | 30943028 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate receptor 2 | 3 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate receptor 4 | 2 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate receptor 3 | 2 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate receptor 1 | 2 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Unchecked | 1 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate receptor ionotropic, AMPA | 1 |
| 30943028 | 10.1021/acs.jmedchem.8b01986 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine